Article
High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice.
Clinical science (London, England : 1979) - 1 Jun 2017
Krishna Smriti Murali, Seto Sai Wang, Jose Roby, Li Jiaze, Moxon Joseph, Clancy Paula, Crossman David J, Norman Paul, Emeto Theophilus I, Golledge Jonathan
Abstract excerpt
Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized by progressive weakening and dilatation of the aortic wall. Thrombospondin-1 (TSP-1; gene Thbs1) is a member of the matricellular protein family important in the control of extracellular matrix (ECM) remodelling. In the present study, the association of serum TSP-1 concentration with AAA progression was assessed in 276 men that...
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