Article
Effects of thrombospondin-4 on pro-inflammatory phenotype differentiation and apoptosis in macrophages.
Cell death & disease - 23 Jan 2020
Rahman Mohammed Tanjimur, Muppala Santoshi, Wu Jiahui, Krukovets Irene, Solovjev Dmitry, Verbovetskiy Dmitriy, Obiako Chioma, Plow Edward F, Stenina-Adognravi Olga
Abstract excerpt
Thrombospondin-4 (TSP-4) attracted renewed attention recently as a result of assignment of new functions to this matricellular protein in cardiovascular, muscular, and nervous systems. We have previously reported that TSP-4 promotes local vascular inflammation in a mouse atherosclerosis model. A common variant of TSP-4, P387-TSP-4, was associated with increased cardiovascular disease risk in human population...
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