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Thrombospondin-1 in maladaptive aging responses: a concept whose time has come

6 May 2020

Abstract excerpt

Numerous age-dependent alterations at the molecular, cellular, tissue and organ systems levels underlie the pathophysiology of aging. Herein, the focus is upon the secreted protein thrombospondin-1 (TSP1) as a promoter of aging and age-related diseases. TSP1 has several physiological functions in youth, including promoting neural synapse formation, mediating responses to ischemic and genotoxic stress, minimizing...

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PMID: 32374675
DOI: 10.1152/ajpcell.00089.2020

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