Article
Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and exercise capacity in mice.
Experimental physiology - 1 Jun 2009
Malek Moh H, Olfert I Mark
Abstract excerpt
Thrombospondin-1 (TSP-1) is a known inhibitor of angiogenesis; however, a skeletal muscle phenotype of TSP-1 null mice has not been investigated. The purposes of this study were to compare and contrast TSP-1 null and wild-type mice by examining the following: (1) capillarity in the skeletal and cardiac muscles; (2) fibre type composition and oxidative enzyme activity in the hindlimb; and (3) the consequences of...
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