Article

Glucocorticoid Receptor ablation promotes cardiac regeneration by hampering cardiomyocyte terminal differentiation

2020-01-15

Abstract excerpt

<h4>ABSTRACT</h4> In mammals, glucocorticoid levels rise dramatically shortly before birth and prepare the foetus for post-natal life by promoting the maturation of the lungs and other organs. However, their impact on cardiac postnatal growth and regenerative plasticity is unknown. Here, we demonstrate that exposure to endogenous glucocorticoids facilitates cell cycle exit and reduces the proliferation of neonata...

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Literature Corpus work: 1e312783-933b-5c9c-9a2f-2c7da49ef528
DOI: 10.1101/2020.01.15.901249

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