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Article

Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse.

The Journal of steroid biochemistry and molecular biology - 1 Mar 2007

Simpson Robert U, Hershey Steven H, Nibbelink Karl A

Abstract excerpt

Our previous studies showed vitamin D deficiency results in increased cardiac contractility, hypertrophy and fibrosis and has profound effects on heart proteomics, structure and function in rat. In this study we found that the heart in vitamin D receptor knockout (VDR-KO) mice is hypertrophied. Six homozygous VDR knockout (-/-), six wild type (+/+) and six heterozygous (+/-) mice were fed a diet containing 2% Ca,...

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Identifiers

PMID: 17275289
DOI: 10.1016/j.jsbmb.2006.12.098
PMCID: PMC1868539

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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