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Mapping genetic interactions in cancer: a road to rational combination therapies

22 Oct 2019

Abstract excerpt

The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2-mutated breast or ovarian cancer. Studies following the initial observation of synthetic lethality demonstrated that the reach of PARP inhibitors is well beyond just...

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PMID: 31640753
DOI: 10.1186/s13073-019-0680-4

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