Article
A new high-throughput method for simultaneous detection of drug resistance associated mutations in Plasmodium vivax dhfr, dhps and mdr1 genes.
Malaria journal - 24 Sept 2011
Barnadas Céline, Kent David, Timinao Lincoln, Iga Jonah, Gray Laurie R, Siba Peter, Mueller Ivo, Thomas Peter J, Zimmerman Peter A
Abstract excerpt
BACKGROUND: Reports of severe cases and increasing levels of drug resistance highlight the importance of improved Plasmodium vivax case management. Whereas monitoring P. vivax resistance to anti-malarial drug by in vivo and in vitro tests remain challenging, molecular markers of resistance represent a valuable tool for high-scale analysis and surveillance studies. A new high-throughput assay for detecting the...
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