Article
Molecular surveillance of Plasmodium vivax dhfr and dhps mutations in isolates from Afghanistan.
Malaria journal - 14 Mar 2010
Zakeri Sedigheh, Afsharpad Mandana, Ghasemi Faezeh, Raeisi Ahmad, Safi Najibullah, Butt Waqar, Atta Hoda, Djadid Navid D
Abstract excerpt
BACKGROUND: Analysis of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutations in Plasmodium vivax wild isolates has been considered to be a valuable molecular approach for mapping resistance to sulphadoxine-pyrimethamine (SP). The present study investigates the frequency of SNPs-haplotypes in the dhfr and dhps genes in P. vivax clinical isolates circulating in two malaria endemic areas in...
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