Article
Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda.
Malaria journal - 14 Mar 2014
Nankoberanyi Sheila, Mbogo George W, LeClair Norbert P, Conrad Melissa D, Tumwebaze Patrick, Tukwasibwe Stephen, Kamya Moses R, Tappero Jordan, Nsobya Samuel L, Rosenthal Philip J
Abstract excerpt
BACKGROUND: Malaria remains a major public health problem, and its control has been hampered by drug resistance. For a number of drugs, Plasmodium falciparum single nucleotide polymorphisms (SNPs) are associated with altered drug sensitivity and can be used as markers of drug resistance. Several techniques have been studied to assess resistance markers. The most widely used methodology is restriction fragment...
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