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Article

Aberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt.

Gut - 1 Jun 2012

Langeveld Danielle, Jansen Marnix, de Boer D V, van Sprundel Mariska, Brosens Lodewijk A A, Morsink Folkert H, Giardiello Francis M, Offerhaus G Johan A, de Leng Wendy W J

Abstract excerpt

OBJECTIVE: Genetic predisposition to cancer in Peutz-Jeghers syndrome (PJS) and the role of germline serine-threonine kinase (LKB1) mutations are poorly understood. The authors studied the effect of germline LKB1 mutations on intestinal stem cell dynamics in unaffected flat PJS mucosa. Recent research has documented that the intestinal crypt houses multiple equipotent stem cell lineages. Lineages continuously...

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Identifiers

PMID: 21940722
DOI: 10.1136/gutjnl-2011-300622
PMCID: PMC3564664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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