Article
Oncogenic anaplastic lymphoma kinase (ALK) mutation in neuroblastomas and other pediatric tumors.
Pathology, research and practice - 15 Oct 2011
Kwon Mi Jung, Choi Yoon-La, Sung Ki Woong, Kang So Young, Park Sang Mo, Choi Song-Yi, Kim Jung-Sun, Suh Yeon-Lim
Abstract excerpt
Neuroblastoma (NB) is one of the most common malignant pediatric tumors that show aggressive behavior. Most advanced-stage NBs have proven refractory to many treatment modalities, and a fundamental alternative therapy, such as inhibition of biological pathways, is now being explored. Anaplastic lymphoma kinase (ALK) has recently been identified as an activation mutation in familial or high-risk sporadic NBs. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.