Article

Time-of-day defines the efficacy of NAD <sup>+</sup> to treat diet-induced metabolic disease by adjusting oscillations of the hepatic circadian clock

2022-08-15

Abstract excerpt

<h4>SUMMARY</h4> The circadian clock is a time-tracking endogenous system which anticipates and coordinates adaptation to daily environmental fluctuations. Circadian misalignment leads to obesity, which is accompanied by reduced levels of the clock-controlled metabolite NAD + . Concomitantly, increasing NAD + levels is emerging as a therapy for diet-induced obesity and type 2 diabetes; however, the impact of da...

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Literature Corpus work: 2a7110c6-be89-582d-8f2a-6fc21c5b1bf9
DOI: 10.1101/2022.08.12.503453

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Time-of-day defines the efficacy of NAD <sup>+</sup> to treat diet-induced metabolic disease by adjusting oscillations of the hepatic circadian clockDOI 10.1101/2022.08.12.503453Read

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