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Article

Regulation of u-PAR gene expression by H2A.Z is modulated by the MEK-ERK/AP-1 pathway.

Nucleic acids research - 1 Jan 2012

Chauhan Santosh, Boyd Douglas D

Abstract excerpt

The urokinase receptor (u-PAR) which is largely regulated at the transcriptional level has been implicated in tumor progression. In this study, we explored the epigenetic regulation of u-PAR and showed that the histone variant H2A.Z negatively regulates its expression in multiple cell lines. Chromatin immunoprecipitation assays revealed that H2A.Z was enriched at previously characterized u-PAR-regulatory regions...

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Share to MAP Kinase Signaling System
Share to Enhancer Elements, Genetic
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to Matrix Metalloproteinase 9

Share to Mitogen-Activated Protein Kinase Kinases

Share to Receptors, Urokinase Plasminogen Activator

Share to Transcription Factor AP-1

Source

Open in PubMed Open full text

Identifiers

PMID: 21937508
DOI: 10.1093/nar/gkr725
PMCID: PMC3258129

Genes

MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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