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Article

PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity.

Molecular cell - 19 Jan 2017

Luo Xin, Ryu Keun Woo, Kim Dae-Seok, Nandu Tulip, Medina Carlos J, Gupte Rebecca, Gibson Bryan A, Soccio Raymond E, Yu Yonghao, Gupta Rana K, Kraus W Lee

Abstract excerpt

Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins mediated by PARP family members, such as PARP-1. Although PARylation has been studied extensively, few examples of definitive biological roles for site-specific PARylation have been reported. Here we show that C/EBPβ, a key pro-adipogenic transcription factor, is PARylated by PARP-1 on three amino acids in a conserved regulatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28107648
DOI: 10.1016/j.molcel.2016.11.015
PMCID: PMC5258183

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