Article
Activation of p21 by HDAC inhibitors requires acetylation of H2A.Z.
PloS one - 1 Jan 2013
Bellucci Luca, Dalvai Mathieu, Kocanova Silvia, Moutahir Fatima, Bystricky Kerstin
Abstract excerpt
Differential positioning of the histone variant H2A.Z in a p53 dependent manner was shown to regulate p21 transcription. Whether H2A.Z is involved in p21 activity in the absence of p53 is not known. The p21 gene is repressed in estrogen receptor (ER) negative cell lines that are p53-/- and hormone independent for their growth. Here we demonstrate that class I and II pan Histone deacetylase inhibitors (HDACi)...
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