Article
Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population.
Hepatology (Baltimore, Md.) - 1 Mar 2012
Doi Hiroyoshi, Iyer Tara K, Carpenter Erica, Li Hong, Chang Kyong-Mi, Vonderheide Robert H, Kaplan David E
Abstract excerpt
UNLABELLED: Chronic hepatitis C virus (HCV) infection is a leading cause of cirrhosis and hepatocellular carcinoma (HCC). Both advanced solid tumors and HCV have previously been associated with memory B-cell dysfunction. In this study, we sought to dissect the effect of viral infection, cirrhosis, and liver cancer on memory B-cell frequency and function in the spectrum of HCV disease. Peripheral blood from...
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