Article
Expansion of functionally anergic CD21-/low marginal zone-like B cell clones in hepatitis C virus infection-related autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2011
Terrier Benjamin, Joly Florence, Vazquez Thomas, Benech Philippe, Rosenzwajg Michelle, Carpentier Wassila, Garrido Marlène, Ghillani-Dalbin Pascale, Klatzmann David, Cacoub Patrice, Saadoun David
Abstract excerpt
Homeostasis of peripheral B cell subsets is disturbed during chronic hepatitis C virus (HCV) infection, leading to the occurrence of autoimmunity and B cell lymphoproliferation. However, mechanisms by which HCV causes lymphoproliferation remain controversial. We report in this article on the elevated number of clonal CD21(-/low)IgM(+)CD27(+) marginal zone (MZ)-like B cells, which correlates with autoimmunity and...
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