Article
CD8+T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunction.
EBioMedicine - 1 Nov 2019
Lebossé Fanny, Gudd Cathrin, Tunc Enes, Singanayagam Arjuna, Nathwani Rooshi, Triantafyllou Evangelos, Pop Oltin, Kumar Naveenta, Mukherjee Sujit, Hou Tie Zheng, Quaglia Alberto, Zoulim Fabien, Wendon Julia, Dhar Ameet, Thursz Mark, Antoniades Charalambos G, Khamri Wafa
Abstract excerpt
BACKGROUND: Cirrhosis-associated immune dysfunction (CAID) contributes to high sepsis risk in patients with chronic liver disease. Various innate and; to a lesser extent; adaptive immune dysfunctions have been described as contributors to CAID leading to immune-paresis and impaired anti-microbial response in cirrhosis. In this study, we examined the phenotype of CD8+T cells in chronic liver disease with the aim...
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