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Article

Attenuated mutants of the intracellular bacterium Listeria monocytogenes obtained by single amino acid substitutions in listeriolysin O.

Molecular microbiology - 1 Dec 1990

Michel E, Reich K A, Favier R, Berche P, Cossart P

Abstract excerpt

Listeriolysin O (LLO), a major virulence factor of the intracellular bacterium Listeria monocytogenes, shares with other known 'thiol-activated toxins' a conserved undecapeptide, ECTGLAWEWWR, located in the C-terminal region of the protein and containing the unique cysteine of the molecule. Single amino acid substitutions were created in this region to study the role of cysteine and tryptophan residues in the...

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PMID: 1965218
DOI: 10.1111/j.1365-2958.1990.tb00578.x

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