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Article

A fast algorithm to optimize SNP prioritization for gene-gene and gene-environment interactions.

Genetic epidemiology - 1 Nov 2011

Deng Wei Q, Paré Guillaume

Abstract excerpt

Detection of gene-environment interactions using an exhaustive search necessarily raises the multiple hypothesis problem. While frequently used to control for experiment-wise type I error, Bonferroni correction is overly conservative and results in reduced statistical power. We have previously shown that prioritizing SNPs on the basis of heterogeneity in quantitative trait variance per genotype leads to increased...

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PMID: 21922538
DOI: 10.1002/gepi.20624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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