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Article

An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction.

Biological psychiatry - 15 Jul 2011

Moskvina Valentina, Craddock Nick, Müller-Myhsok Bertram, Kam-Thong Tony, Green Elaine, Holmans Peter, Owen Michael J, O'Donovan Michael C

Abstract excerpt

BACKGROUND: Given that genome-wide association studies (GWAS) of psychiatric disorders have identified only a small number of convincingly associated variants (single nucleotide polymorphism [SNP]), there is interest in seeking additional evidence for associated variants with tests of gene-gene interaction. Comprehensive pair-wise single SNP-SNP interaction analysis is computationally intensive, and the penalty...

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Identifiers

PMID: 21481336
DOI: 10.1016/j.biopsych.2011.01.034
PMCID: PMC3125485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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