Article
Prioritized subset analysis: improving power in genome-wide association studies.
Human heredity - 1 Jan 2008
Li Chun, Li Mingyao, Lange Ethan M, Watanabe Richard M
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) are now feasible for studying the genetics underlying complex diseases. For many diseases, a list of candidate genes or regions exists and incorporation of such information into data analyses can potentially improve the power to detect disease variants. Traditional approaches for assessing the overall statistical significance of GWAS results ignore such...
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