Article
SNP prioritization using a Bayesian probability of association.
Genetic epidemiology - 1 Feb 2013
Thompson John R, Gögele Martin, Weichenberger Christian X, Modenese Mirko, Attia John, Barrett Jennifer H, Boehnke Michael, De Grandi Alessandro, Domingues Francisco S, Hicks Andrew A, Marroni Fabio, Pattaro Cristian, Ruggeri Fabrizio, Borsani Giuseppe, Casari Giorgio, Parmigiani Giovanni, Pastore Andrea, Pfeufer Arne, Schwienbacher Christine, Taliun Daniel, Fox Caroline S, Pramstaller Peter P, Minelli Cosetta
Abstract excerpt
Prioritization is the process whereby a set of possible candidate genes or SNPs is ranked so that the most promising can be taken forward into further studies. In a genome-wide association study, prioritization is usually based on the P-values alone, but researchers sometimes take account of external annotation information about the SNPs such as whether the SNP lies close to a good candidate gene. Using external...
Topics
- Bayes Theorem
- Databases, Genetic
- Genome-Wide Association Study
- Humans
- Kidney
- Meta-Analysis as Topic
- Models, Genetic
- Polymorphism, Single Nucleotide