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Article

Abolishing myofibroblast arrhythmogeneicity by pharmacological ablation of α-smooth muscle actin containing stress fibers.

Circulation research - 28 Oct 2011

Rosker Christian, Salvarani Nicolò, Schmutz Stephan, Grand Teddy, Rohr Stephan

Abstract excerpt

RATIONALE: Myofibroblasts typically appear in the myocardium after insults to the heart like mechanical overload and infarction. Apart from contributing to fibrotic remodeling, myofibroblasts induce arrhythmogenic slow conduction and ectopic activity in cardiomyocytes after establishment of heterocellular electrotonic coupling in vitro. So far, it is not known whether α-smooth muscle actin (α-SMA) containing...

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Identifiers

PMID: 21921266
DOI: 10.1161/CIRCRESAHA.111.244798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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