Article
Investigation of cardiac fibroblasts using myocardial slices.
Cardiovascular research - 1 Jan 2018
Perbellini Filippo, Watson Samuel A, Scigliano Martina, Alayoubi Samha, Tkach Sebastian, Bardi Ifigeneia, Quaife Nicholas, Kane Christopher, Dufton Neil P, Simon André, Sikkel Markus B, Faggian Giuseppe, Randi Anna M, Gorelik Julia, Harding Sian E, Terracciano Cesare M
Abstract excerpt
Aims: Cardiac fibroblasts (CFs) are considered the principal regulators of cardiac fibrosis. Factors that influence CF activity are difficult to determine. When isolated and cultured in vitro, CFs undergo rapid phenotypic changes including increased expression of α-SMA. Here we describe a new model to study CFs and their response to pharmacological and mechanical stimuli using in vitro cultured mouse, dog and...
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