Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic activation of human cardiac fibroblasts in vitro attenuates the reversibility of the myofibroblast phenotype.

Scientific reports - 26 Jul 2023

Hall Caitlin, Law Jonathan P, Reyat Jasmeet S, Cumberland Max J, Hang Shaun, Vo Nguyen T N, Raniga Kavita, Weston Chris J, O'Shea Christopher, Townend Jonathan N, Gehmlich Katja, Ferro Charles J, Denning Chris, Pavlovic Davor

Abstract excerpt

Activation of cardiac fibroblasts and differentiation to myofibroblasts underlies development of pathological cardiac fibrosis, leading to arrhythmias and heart failure. Myofibroblasts are characterised by increased α-smooth muscle actin (α-SMA) fibre expression, secretion of collagens and changes in proliferation. Transforming growth factor-beta (TGF-β) and increased mechanical stress can initiate myofibroblast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Fibroblasts

Share to Induced Pluripotent Stem Cells

Share to Myofibroblasts

Share to Transforming Growth Factor beta

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 37495732
DOI: 10.1038/s41598-023-39369-y
PMCID: PMC10372150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic activation of human cardiac fibroblasts in vitro attenuates the reversibility of the myofibroblast phenotype.PMID 37495732Read ↗

Maintaining resting cardiac fibroblasts in vitro by disrupting mechanotransduction.Semantic proximity Read ↗

Soft Substrate Culture to Mechanically Control Cardiac Myofibroblast Activation.Semantic proximity Read ↗

Featured Article: TGF-β1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblastsSemantic proximity Read ↗

Persistent Fibrosis in Heart Failure With a Reduced Ejection Fraction Linked to Phenotypic Differences in Human Cardiac Fibroblast Populations.Semantic proximity Read ↗

Investigation of cardiac fibroblasts using myocardial slices.Semantic proximity Read ↗

Mechanical regulation of cardiac fibroblast profibrotic phenotypes.Semantic proximity Read ↗

Robust Generation of Quiescent Porcine Valvular Interstitial Cell CulturesSemantic proximity Read ↗

Mechanomemory of pulmonary fibroblasts demonstrates reversibility of transcriptomics and contraction phenotypes.Semantic proximity Read ↗

Cardiac fibroblasts influence cardiomyocyte phenotype in vitro.Semantic proximity Read ↗

Cardiac fibroblasts in cell culture systems: myofibroblasts all along?Semantic proximity Read ↗

Persistent phenotypic shift in cardiac fibroblasts: impact of transient renin angiotensin system inhibition.Semantic proximity Read ↗

Fibroblast growth factor 2 inhibits myofibroblastic activation of valvular interstitial cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.