Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion.

Cardiovascular research - 1 Nov 2014

Hariharan Venkatesh, Asimaki Angeliki, Michaelson Jarett E, Plovie Eva, MacRae Calum A, Saffitz Jeffrey E, Huang Hayden

Abstract excerpt

AIMS: The majority of patients diagnosed with arrhythmogenic right ventricular cardiomyopathy (ARVC) have mutations in genes encoding desmosomal proteins, raising the possibility that abnormal intercellular adhesion plays an important role in disease pathogenesis. We characterize cell mechanical properties and molecular responses to oscillatory shear stress in cardiac myocytes expressing mutant forms of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrhythmogenic Right Ventricular Dysplasia
Share to gamma Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to Intercellular Junctions

Share to Mechanotransduction, Cellular

Share to Plakophilins

Share to Stress, Mechanical

Source

Open in PubMed Open full text

Identifiers

PMID: 25253076
DOI: 10.1093/cvr/cvu212
PMCID: PMC4296114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion.PMID 25253076Read ↗

Arrhythmogenic right ventricular cardiomyopathy: new insights into disease mechanisms and diagnosis.Semantic proximity Read ↗

Genetics of right ventricular cardiomyopathy.Semantic proximity Read ↗

Molecular biology and clinical management of arrhythmogenic right ventricular cardiomyopathy/dysplasia.Semantic proximity Read ↗

Disparate effects of different mutations in plakoglobin on cell mechanical behavior.Semantic proximity Read ↗

A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctionsSemantic proximity Read ↗

Arrhythmogenic Right Ventricular Cardiomyopathy Plakophilin-2 Mutations Disrupt Desmosome Assembly and StabilitySemantic proximity Read ↗

Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathySemantic proximity Read ↗

Arrhythmogenic cardiomyopathy and abnormalities of cell-to-cell coupling.Semantic proximity Read ↗

Mechanobiology of myofibroblast adhesion in fibrotic cardiac diseaseSemantic proximity Read ↗

Calcium as a Key Player in Arrhythmogenic Cardiomyopathy: Adhesion Disorder or Intracellular Alteration?Semantic proximity Read ↗

Cardiac Tissue-Restricted Deletion of Plakoglobin Results in Progressive Cardiomyopathy and Activation of β-Catenin SignalingSemantic proximity Read ↗

Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.