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Article

Integrin activation in the heart: a link between electrical and contractile dysfunction?

Circulation research - 8 Dec 2006

Valencik Maria L, Zhang Dongfang, Punske Bonnie, Hu Ping, McDonald John A, Litwin Sheldon E

Abstract excerpt

Integrins mechanically link the cytoskeleton to the extracellular matrix in cardiac myocytes and are thereby involved in mechanotransduction. Integrins appear to be necessary for cardiac myocyte hypertrophy. To determine the effect of increased integrin ligation and signaling on adult cardiac function, a heart-specific truncated alpha(5) integrin (gain of function) was conditionally expressed in mice. Four days...

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Identifiers

PMID: 17095723
DOI: 10.1161/01.RES.0000252291.88540.ac

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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