Article
CD4⁺CD25⁺/highCD127low/⁻ regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints--analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood.
Arthritis research & therapy - 17 Apr 2014
Moradi Babak, Schnatzer Philipp, Hagmann Sébastien, Rosshirt Nils, Gotterbarm Tobias, Kretzer Jan Philippe, Thomsen Marc, Lorenz Hanns-Martin, Zeifang Felix, Tretter Theresa
Abstract excerpt
INTRODUCTION: CD4⁺CD25⁺/highCD127low/⁻ regulatory T cells (Tregs) play a crucial role in maintaining peripheral tolerance. Data about the frequency of Tregs in rheumatoid arthritis (RA) are contradictory and based on the analysis of peripheral blood (PB) and synovial fluid (SF). Because Tregs exert their anti-inflammatory activity in a contact-dependent manner, the analysis of synovial membrane (SM) is crucial....
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