DNA hypermethylation of the forkhead box protein 3 (<i>FOXP3</i>) promoter in CD4+ T cells of patients with systemic sclerosis

Abstract excerpt

BACKGROUND: Systemic sclerosis (SSc) is a complex autoimmune disease that involves dysregulation of immune homeostasis. The failure of impaired regulatory T cells (Tregs) to maintain immune homeostasis plays a major role in the development of SSc. Transcriptional silencing of the forkhead box protein 3 gene (FOXP3) via hypermethylation of regulatory regions has been identified as a hallmark of committed Tregs and...

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