Article
Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.
Thorax - 1 Dec 2011
Brehm John M, Hagiwara Koichi, Tesfaigzi Yohannes, Bruse Shannon, Mariani Thomas J, Bhattacharya Soumyaroop, Boutaoui Nadia, Ziniti John P, Soto-Quiros Manuel E, Avila Lydiana, Cho Michael H, Himes Blanca, Litonjua Augusto A, Jacobson Francine, Bakke Per, Gulsvik Amund, Anderson Wayne H, Lomas David A, Forno Erick, Datta Soma, Silverman Edwin K, Celedón Juan C
Abstract excerpt
RATIONALE: Traditional genome-wide association studies (GWASs) of large cohorts of subjects with chronic obstructive pulmonary disease (COPD) have successfully identified novel candidate genes, but several other plausible loci do not meet strict criteria for genome-wide significance after correction for multiple testing. OBJECTIVES: The authors hypothesise that by applying unbiased weights derived from unique...
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