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Article

Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology - 15 Apr 2012

Richards Thomas J, Park Chunghyun, Chen Yiliang, Gibson Kevin F, Peter Di Y, Pardo Annie, Watkins Simon C, Choi Augustine M K, Selman Moises, Pilewski Joseph, Kaminski Naftali, Zhang Yingze

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a complex disease with poorly understood etiology. Previously, we reported upregulation of matrix metalloproteinase 7 (MMP7) in both lung and peripheral blood of IPF patients. Here we report evidence for genetic correlation of plasma levels and promoter polymorphisms (rs11568818 and rs11568819) of MMP7 in a well-characterized IPF cohort. Both the AA genotype of rs11568818...

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Share to Hepatocyte Nuclear Factor 3-beta
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Share to Polymorphism, Genetic
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Source

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Identifiers

PMID: 22268124
DOI: 10.1152/ajplung.00319.2011
PMCID: PMC3331579

Genes

MMP7
FOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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