Article
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations.
American journal of respiratory cell and molecular biology - 1 Jul 2005
Hersh Craig P, Demeo Dawn L, Lange Christoph, Litonjua Augusto A, Reilly John J, Kwiatkowski David, Laird Nan, Sylvia Jody S, Sparrow David, Speizer Frank E, Weiss Scott T, Silverman Edwin K
Abstract excerpt
Case-control studies have successfully identified many significant genetic associations for complex diseases, but lack of replication has been a criticism of case-control genetic association studies in general. We selected 12 candidate genes with reported associations to chronic obstructive pulmonary disease (COPD) and genotyped 29 polymorphisms in a family-based study and in a case-control study. In the Boston...
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