Article
A genome-wide association study of chronic obstructive pulmonary disease in Hispanics.
Annals of the American Thoracic Society - 1 Mar 2015
Chen Wei, Brehm John M, Manichaikul Ani, Cho Michael H, Boutaoui Nadia, Yan Qi, Burkart Kristin M, Enright Paul L, Rotter Jerome I, Petersen Hans, Leng Shuguang, Obeidat Ma'en, Bossé Yohan, Brandsma Corry-Anke, Hao Ke, Rich Stephen S, Powell Rhea, Avila Lydiana, Soto-Quiros Manuel, Silverman Edwin K, Tesfaigzi Yohannes, Barr R Graham, Celedón Juan C
Abstract excerpt
RATIONALE: Genome-wide association studies (GWAS) of chronic obstructive pulmonary disease (COPD) have identified disease-susceptibility loci, mostly in subjects of European descent. OBJECTIVES: We hypothesized that by studying Hispanic populations we would be able to identify unique loci that contribute to COPD pathogenesis in Hispanics but remain undetected in GWAS of non-Hispanic populations. METHODS: We...
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