Article
Extracellular determinants of anion discrimination of the Cl-/H+ antiporter protein CLC-5.
The Journal of biological chemistry - 23 Dec 2011
De Stefano Silvia, Pusch Michael, Zifarelli Giovanni
Abstract excerpt
Mammalian CLC proteins comprise both Cl- channels and Cl-/H+ antiporters that carry out fundamental physiological tasks by transporting Cl- across plasma membrane and intracellular compartments. The NO3- over Cl- preference of a plant CLC transporter has been pinpointed to a conserved serine residue located at Scen and it is generally assumed that the other two binding sites of CLCs, Sext and Sin, do not...
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