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Article

Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2005

Kidd Elizabeth A, Yu Jinsheng, Li Xia, Shannon William D, Watson Mark A, McLeod Howard L

Abstract excerpt

Although colorectal cancer has the third highest cancer mortality rate, the treatment remains far from optimized with patients showing variable responses to standard treatment. Molecular differences in pharmacologically relevant genes may contribute to the variability in response. This study used Taqman PCR to investigate the expression of 24 5-fluorouracil (5-FU) pathway genes in colorectal cancer using paired...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15814641
DOI: 10.1158/1078-0432.CCR-04-1258

Genes

DHFR
DPYD
FPGS
GGH
NME1
NME2
UMPS
UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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