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Article

Investigation of DPYD, MTHFR and TYMS polymorphisms on 5-fluorouracil related toxicities in colorectal cancer.

Personalized medicine - 1 Sept 2022

Cevik Mehtap, Namal Esat, Sener Nur Dinc, Koksal Ulkuhan Iner, Cagatay Penbe, Deliorman Gokce, Ciftci Cavlan, Karaalp Atila, Susleyici Belgin

Abstract excerpt

Aim: To investigate the association of DPYD, MTHFR and TYMS polymorphisms on 5-fluorouracil (5-FU) related toxicities and patient survival. Materials & methods: A total of 103 colorectal cancer patients prescribed 5-FU were included in the study. Genotyping was conducted for several DPYD, MTHFR and TYMS polymorphisms using a microarray analyzer. Results: DPYD 496A>G polymorphism was found to be significantly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35880438
DOI: 10.2217/pme-2021-0047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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