Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes.

Psychoneuroendocrinology - 1 Apr 2012

Xu Ke, Hong Kwangik Adam, Zhou Zhifeng, Hauger Richard L, Goldman David, Sinha Rajita

Abstract excerpt

BACKGROUND: Neuropeptide Y (NPY) is involved in stress regulation. Genetic variations predict plasma NPY and neural correlates of emotion and stress. We examined whether the functional NPY haplotype modulates stress-induced NPY and anxiety responses, and if plasma NPY stress responses are associated with substance dependence outcomes. METHODS: Thirty-seven treatment-engaged, abstinent substance dependent (SD)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Cues
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Rate

Share to Neuropeptide Y

Share to Recurrence

Share to Stress, Psychological

Share to Substance-Related Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 21917383
DOI: 10.1016/j.psyneuen.2011.08.005
PMCID: PMC3252459

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes.PMID 21917383Read ↗

Genetic variation in human NPY expression affects stress response and emotion.Semantic proximity Read ↗

Emotion processing, major depression, and functional genetic variation of neuropeptide Y.Semantic proximity Read ↗

Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.Semantic proximity Read ↗

Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques.Semantic proximity Read ↗

Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder.Semantic proximity Read ↗

Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.Semantic proximity Read ↗

Drug-induced and genetic alterations in stress-responsive systems: Implications for specific addictive diseases.Semantic proximity Read ↗

Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression.Semantic proximity Read ↗

Examining hypothalamic-pituitary-adrenal axis genetic variation on cortisol and alpha-amylase reactivity during an explicit negative-evaluative stress induction.Semantic proximity Read ↗

Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses.Semantic proximity Read ↗

Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin.Semantic proximity Read ↗

Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.