Article
A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis.
Annals of the rheumatic diseases - 1 Dec 2011
Vazgiourakis Vassilios M, Zervou Maria I, Choulaki Christianna, Bertsias George, Melissourgaki Maria, Yilmaz Neslihan, Sidiropoulos Prodromos, Plant Darren, Trouw Leendert A, Toes Rene E, Kardassis Dimitris, Yavuz Sule, Boumpas Dimitrios T, Goulielmos George N
Abstract excerpt
BACKGROUND: In systemic lupus erythematosus (SLE) sustained CD40L expression by T cells and platelets activates a variety of cells via its receptor CD40 contributing to disease pathogenesis. Although CD40 has recently been identified in genome-wide association study as a novel rheumatoid arthritis susceptibility gene such an association has not been documented for SLE. OBJECTIVE: To investigate whether the...
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