Article
The association of CD40 polymorphisms with CD40 serum levels and risk of systemic lupus erythematosus.
BMC genetics - 16 Oct 2015
Chen Jian-Ming, Guo Jing, Wei Chuan-Dong, Wang Chun-Fang, Luo Hong-Cheng, Wei Ye-Sheng, Lan Yan
Abstract excerpt
BACKGROUND: Current evidence shows that the CD40-CD40 ligand (CD40-CD40L) system plays a crucial role in the development, progression and outcome of systemic lupus erythematosus (SLE). The aim of this study was to investigate whether a CD40 gene single nucleotide polymorphism (SNP) is associated with SLE and CD40 expression in the Chinese population. We included controls (n = 220) and patients with either SLE (n...
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