Executionary pathway for apoptosis: lessons from mutant mice.

doi:10.1038/sj.cr.7290054

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Article

Executionary pathway for apoptosis: lessons from mutant mice.

Cell research - 1 Dec 2000

Woo M, Hakem R, Mak T W

Abstract excerpt

Apoptosis or programmed cell death (PCD) is an evolutionarily conserved cellular process that is essential for normal development and homeostasis of multicellular organisms. Defects in the apoptosis signaling result in many diseases including autoimmune diseases and cancer. The apoptosis signaling pathway was first described genetically in the nematode Caenorhabditis elegans which serves as a framework for the...

Topics

Animals
Apoptosis
Caspases
Mice
Mice, Knockout
Mutation
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 11191349
DOI: 10.1038/sj.cr.7290054

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