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Endoplasmic Reticulum Stress-induced Apoptosis

7 Jan 2006

Abstract excerpt

Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in the development of multiple diseases. However, the in vivo signaling pathways are still not fully understood. In this report, through the use of genetically deficient mouse embryo fibroblasts (MEFs) and their matched wild-type controls, we have demonstrated that the mitochondrial apoptotic pathway mediated by Apaf-1 is an integral part of...

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PMID: 16407291
DOI: 10.1074/jbc.m509868200

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