Article
Apoptosis and carcinogenesis.
British journal of cancer - 1 Jul 1999
Wyllie A H, Bellamy C O, Bubb V J, Clarke A R, Corbet S, Curtis L, Harrison D J, Hooper M L, Toft N, Webb S, Bird C C
Abstract excerpt
Apoptosis has long been known to be effected through a common sequence of structural changes, despite the wide variety of initiating stimuli. These common structural events appear to depend upon activation of a set of enzymes (caspases) which direct a strongly conserved, terminal effector pathway. The regulation of this pathway, and in particular its coupling to DNA damage, appears to be critical in maintaining...
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