Article
The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions.
Oncogene - 17 Jul 2003
Edwards Sara J, Hananeia Lynne, Eccles Michael R, Zhang You Fang, Braithwaite Antony W
Abstract excerpt
The N-terminal proline-rich domain of human p53 has been shown to be important for the induction of apoptosis. However, the corresponding region in mouse and other species is not highly conserved and has been less well studied. In this paper, we have characterized mutants with deletions in this region of mouse p53. Our results demonstrate that deletions in the proline-rich domain have varying effects on function...
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