Article
Clusters of conserved beta cell marker genes for assessment of beta cell phenotype.
PloS one - 1 Jan 2011
Martens Geert A, Jiang Lei, Hellemans Karine H, Stangé Geert, Heimberg Harry, Nielsen Finn C, Sand Olivier, Van Helden Jacques, Van Lommel Leentje, Schuit Frans, Gorus Frans K, Pipeleers Daniel G
Abstract excerpt
BACKGROUND AND METHODOLOGY: The aim of this study was to establish a gene expression blueprint of pancreatic beta cells conserved from rodents to humans and to evaluate its applicability to assess shifts in the beta cell differentiated state. Genome-wide mRNA expression profiles of isolated beta cells were compared to those of a large panel of other tissue and cell types, and transcripts with beta cell-abundant...
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