Article
Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population.
BMC cancer - 10 Sept 2007
Wang Lihong, Li Dalin, Fu Zhenkun, Li Heng, Jiang Wei, Li Dianjun
Abstract excerpt
BACKGROUND: The host immunogenetic background plays an important role in the development of breast cancer. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a molecule expressed predominantly on activated T cells and is important during the down-regulation of T-cell activation. To evaluate the potential influences of CTLA-4 gene polymorphisms on breast cancer risk, a case-control study was conducted in Han women of...
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