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Article

Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Jul 2002

Bonangelino Cecilia J, Chavez Edna M, Bonifacino Juan S

Abstract excerpt

The biosynthetic sorting of hydrolases to the yeast vacuole involves transport along two distinct routes referred to as the carboxypeptidase Y and alkaline phosphatase pathways. To identify genes involved in sorting to the vacuole, we conducted a genome-wide screen of 4653 homozygous diploid gene deletion strains of Saccharomyces cerevisiae for missorting of carboxypeptidase Y. We identified 146 mutant strains...

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Identifiers

PMID: 12134085
DOI: 10.1091/mbc.02-01-0005
PMCID: PMC117329

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