Article
A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk.
Breast cancer research and treatment - 1 Jun 2010
Yang Rongxi, Schlehe Bettina, Hemminki Kari, Sutter Christian, Bugert Peter, Wappenschmidt Barbara, Volkmann Juliane, Varon Raymonda, Weber Bernhard H F, Niederacher Dieter, Arnold Norbert, Meindl Alfons, Bartram Claus R, Schmutzler Rita K, Burwinkel Barbara
Abstract excerpt
MicroRNAs (miRNAs) regulate pathways involved in cell differentiation, proliferation, development, and apoptosis by degradation of target mRNAs and/or repression of their translation. Although the single nucleotide polymorphisms (SNPs) in miRNAs target sites have been studied, the effects of SNPs in miRNAs are largely unknown. In our study, we first systematically sequenced miRNA genes reported to be involved in...
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