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H9 avian influenza reassortant with engineered polybasic cleavage site displays a highly pathogenic phenotype in chicken

28 Apr 2011

Abstract excerpt

In the field, highly pathogenic avian influenza viruses (HPAIV) originate from low-pathogenic strains of the haemagglutinin (HA) serotypes H5 and H7 that have acquired a polybasic HA cleavage site. This observation suggests the presence of a cryptic virulence potential of H5 and H7 low-pathogenic avian influenza viruses (LPAIV). Among all other LPAIV, the H9N2 strains are of particular relevance as they have...

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PMID: 21525207
DOI: 10.1099/vir.0.031591-0

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